The bosses of successful restaurant chain Dylan's have written an open letter to First Minister Mark Drakeford - warning "we are on our knees".
David Evans and Robin Hodgson have built up the brand after launching in 2012 and employ more than 150 staff at restaurants in Llandudno, Menai Bridge and Criccieth and a production hub in Llangefni.
Like the rest of the sector they have been impacted by lockdowns, and restrictions on the sale of alcohol, opening times and guest numbers over the past 12 months.
They are now desperate to get open again but Welsh Government currently doesn't have a reopening date for indoor hospitality while with outdoor hospitality a final decision will be taken on April 22.
In England outdoor hospitality is expected to open on April 12 and indoors on May 17 while Scotland also has a reopening roadmap.
It comes as the seven day rolling infection rate in Wales drops to below 40 per 100,000 people - although on Anglesey where Dylan's is based it is over 100, with a spike in Holyhead the main driver of that high figure.
The joint owners of Dylan's wrote: "How do you expect us to compete with other nations when we are not given the same opportunities?
"Mr Drakeford, we are on our knees. We have exhausted our reserves.
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"Our staff need to work, and our customers need to see our doors open once again.
"Our communities need hospitality venues as safe places to socialise and combat feelings of isolation, detachment and loneliness.
"Small producers and supply chain businesses need restaurants, cafés and pubs to start moving again.
"Every day that the Welsh hospitality industry remains closed - whilst other nations re-open - weakens us all further.
"Please share with us a route out of this, and we will accept the caveats and conditions that come with it.
"The R rate must stay below a certain figure, hospitalisations and deaths must remain at a low level. This goes without saying.
"But we need some answers."
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The updated Welsh Government Coronavirus Control Plan said: "The much higher transmissibility of the Kent variant makes mixing indoors even more risky.
"Allowing for indoor mixing will therefore need to wait until rates are very low and vaccines are rolled out to more of the population."
Plaid Cymru Leader Adam Price said that Welsh business had been “left in the dark” when it came to re-opening with no targets or dates on when they can expect to re-open safely for trading and called for a clearer roadmap to provide businesses with greater clarity.
Mr Price also called for more financial support for Welsh hospitality and leisure businesses in the form of one-off restart grants to help with the costs of re-opening.
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Welsh independent hospitality businesses have said the next seven days are going to be critical for the survival of many in its sector.
The financial support measures currently in place for restaurants, cafes and pubs across Wales will expire on March 31, and with no word yet from Welsh Government on further support after that date.
“Thousands of small independent hospitality businesses are staring into the void with no answer as to when they can begin trading and no indication of if and when they might receive financial support to plug the gap,” said Simon Wright, independent restaurateur and one of the co-founders of the Welsh Independent Restaurant Collective (WIRC).
WIRC warns that the impact on jobs would be catastrophic, and will undermine previous efforts to keep independent hospitality businesses across Wales alive and ready to be part of the country’s economic recovery.
Kasim Ali, founder of the Waterloo Tea chain of tea houses in South Wales said: “The Government has said that it’s committed to the foundational economy and the principle of recovery based on the creativity, energy and growth potential of small Welsh businesses.
"This contrasts with their actions over the past few weeks which seem out of kilter with those objectives. Independent “non-essential” retail remains closed whilst supermarkets and other large stores mop up the pent-up demand from the public.
"In hospitality we face a grim uncertainty with no word on funding and no real sense of when we might begin to trade again. The mood amongst all who work in the sector is one of great anxiety, an anxiety that could be substantially lifted by Welsh Government breaking their silence on funding available post March 31."
David Chapman, executive director of 海角视频Hospitality Cymru, said: "Throughout 海角视频HC has led on funding and further funding (and this has led to the higher levels of support we have seen in Wales compared to England and Scotland) and I have been pressing for the need for new financial year support to be put in place since before the awards of ERFSSF 2 were announced- as early as January.
"I have been assured that we will receive more funding from April 1 for our businesses that are unable to open or that will have to trade in the much-restricted sub viable manner and we currently wait to see what form that will take."
Welsh Government is expected to give an update on funding on Friday.