Greater Manchester Mayor Andy Burnham has called for resignations as the fall out of Number 10's alleged Christmas party last year continues.
The mayor added the news coming out of Westminster is making the jobs of front line NHS staff in the city region "even harder".
Mr Burnham also called on residents to not get distracted" by the news and to continue to help the city to fight against the pandemic.
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Speaking to journalists at a virtual press conference, the mayor called for more information to be released by Number 10 as well as "accountability for what happened" and resignations "if necessary".
Mr Burnham said the news is having a "dispiriting" impact on people in Greater Manchester.
He also said the number of suspected Omicron cases in the city region had gone from two last week to "high double figures".
Mr Burnham told journalists: "I can understand the frustration people have. So many people have sacrificed so much in the North West. [This time last year] was really hard for people."
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The mayor also said that it appears to be a "do as I say not as I do" attitude from the Government.
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He called on people in Greater Manchester to "not get distracted" by the news and that they "have got to do what is right" for the city region.
Referencing PMQs which was held earlier today, Mr Burnham said: "I have been in politics a long time and I know that you do not have to rehearse lines for something that did not happen.
"We are not being told the full truth and I do not believe this can continue.
"We have to be told everything that known that happened last year and that has to happen immediately.
"I have been a minister in Government and there is always a full record of what has happened in Number 10. That should be released.
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"There has to be accountability for what happened and if necessary, there must be resignations."
Separately, the mayor also confirmed that City Mayor of Salford, Paul Dennett, has become deputy mayor of Greater Manchester, following Sir Richard Leese stepping down as leader of Manchester City Council.