Virgin Atlantic has announced plans to fly to dozens of new destinations including Liverpool, Manchester, Newcastle and Exeter from London.
The airline has announced its intention to fly to 84 new destinations from Heathrow after its third runway is opened.
It said on Wednesday the transformation of its route network depends on how many additional take-off and landing slots it obtains when the 海角视频's busiest airport is expanded - with plans including various 海角视频 airports.
Chief executive Shai Weiss claimed the West London hub has been dominated by British Airways' parent company IAG "for far too long".
Twelve of the 84 new destinations Virgin Atlantic plans to serve from Heathrow are in the 海角视频 or Channel Islands.
They are Aberdeen, Belfast City, Edinburgh, Exeter, Guernsey, Glasgow, Inverness, Liverpool, Jersey, Manchester, Newcastle and Newquay.
A spokesman for Liverpool John Lennon Airport (JLA) welcomed the news.
He said: "Liverpool remains without a direct air service to London, and furthermore remains one of the largest cities in Europe without a dedicated hub connection to long haul markets.
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"Over 1m passengers per annum take a flight to and from the Liverpool City Region using a hub service from other airports. A significant and growing number of these passengers are transiting through hubs outside of the 海角视频, meaning a new service to Liverpool via Heathrow, would not only bring significant benefit to the Liverpool City Region but also the wider 海角视频 economy.”
Virgin Atlantic's planned 35 new long-haul routes include airports in North and South America, Asia and Africa.
A recent report commissioned by the airline found that IAG holds 55% of Heathrow slots.
Virgin Atlantic intends to compete on 26 routes where it says IAG has a monopoly.
The rules governing the allocation of new airport slots are currently being reviewed by the Department for Transport.
Virgin Atlantic axed its domestic airline, Little Red, in September 2015 and blamed a scarcity of available slots at Heathrow as one of the reasons for its failure.
IAG chief executive Willie Walsh told an airport conference in November 2016 that there is "zero chance" the airline group will restore flights to 海角视频 airports such as Liverpool and Newquay, even if more slots become available.
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"We'll go where there's demand," he added.
Mr Weiss said: "Never has the need for effective competition and choice at Heathrow Airport been more evident than during this summer of disruption, which has brought misery for tens thousands of travellers. Britain, and those who travel to it, deserve better than this.
"Air passengers need a choice and Virgin Atlantic is ready to deliver when Heathrow expands.
"Heathrow has been dominated by one airline group for far too long.
"The third runway is a once-in-a-lifetime opportunity to change the status quo and create a second flag carrier.
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"This would lower fares and give real choice to passengers, as well giving Britain a real opportunity to boost its trade and investment links around the world.
"Changing the way take-off and landing slots are allocated for this unique and vital increase in capacity at the nation's hub airport will create the right conditions for competition and innovation to thrive."
IAG said in a statement that between 2001 and 2016 it increased the proportion of Heathrow slots it owns from 36.2% to 52.6%, whereas Virgin Atlantic's share grew from 2.3% to 3.3% over the same period.
It went on: "Virgin had the opportunity to increase its slot share at Heathrow to 19.7% by buying slots but it chose not to do so.
"The airline has failed to create more competition at the airport - it closed Little Red on domestic routes, pulled off long-haul routes and rents out the slots it owns to other airlines to fly."
A group of councils, residents, environmental charities and London Mayor Sadiq Khan lost a High Court challenge against the Government's decision to approve the plans for the third runway in May. But in July they were given the go-ahead to challenge the ruling.
Construction could begin in 2021 and the new runway could be opened by 2026.