Lower speed limits are set to be introduced this week on certain sections of the A38 in Cornwall.
It comes after 60 collisions over a five-year period, which resulted in 97 casualties and two deaths, transport body National Highways said.
From Wednesday (August 20) road users travelling through the villages of Tideford and Landrake will see a new speed limit of 30mph, down from 40mph, with two spot speed cameras.
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The speed change follows the completion of work to install 10 average speed cameras, managing the 50mph limit between the Carkeel roundabout and Trerulefoot.
The £750,000 scheme is being jointly delivered on site by the Vision Zero partnership - a collaborative project between a number of organisations across Devon and Cornwall.
The local police force is responsible for the enforcement of the speed limits.
Jack Mason, National Highways’ South West road safety manager, said: “We’re thrilled to have delivered a scheme that will ensure safer journeys for road users and the local community."
The six-mile stretch of road sees a daily average of 23,600 journeys, Mr Mason said, and the speed changes will aim to reduce the number of people harmed along the busy single lane section.
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Cllr Dan Rogerson, Cornwall Council cabinet member for transport, said: “The council has been working with the local community to improve safety at this location.
“It’s clear that – used in the right locations - average speed cameras and lower speed limits, reduce collisions and make our roads safer.
“We are committed to providing connected, reliable and safe transport that works for the people of Cornwall – and our work with partners here is a prime example of that.”
Anna Gelderd, MP for South East Cornwall, said taking action to improve safety along "dangerous stretches" of the A38 had been a "key issue" for people across the county for years.
Adrian Leisk, head of road safety for Devon & Cornwall Police, added: “The local community have championed the need for a 24-hour monitoring presence, and I know they will warmly welcome these interventions.
"Average Speed Enforcement schemes have incredibly high levels of immediate speed compliance and deliver added benefits around reducing driver stress and examples of poor driving.”
National Highways said it would be monitoring the effectiveness of the average speed cameras once installed.