The birthplace of both Liverpool and Everton football clubs has been put up for sale for more than £3.7m.
The Sandon Complex has served the local community under various ownership since the 1870s.
It was originally owned by the founder of Liverpool FC, John Houlding.
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Specialist hospitality property adviser Christie & Co is leading the sale of the property.
In 2017, the business was acquired by award-winning, local businesswoman Kate Stewart and underwent an extensive refurbishment.
The venue has a capacity for over 4,500 people spanning across the entire complex, large outdoor screens erected for finals and live music.
Kate Stewart said: "Since purchasing The Sandon in 2017, I have given it the TLC that it needed, regularly investing in the hospitality suites and creating a 115-bed hotel.
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"The Sandon is an institution for football fans, and I have loved welcoming Liverpool FC fans from all over the world, but I've made the difficult decision to retire from the hospitality sector after more than 20 years to dedicate more time to my children; three of which are under six years old.
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"I will miss The Sandon terribly, but I feel this is the right time to close this chapter and spend more time with my family whilst they are still so young."
Tom O’Malley, associate director in Christie & Co’s Hospitality team, added: "With its historical associations and contracts with Liverpool FC, along with its proximity to Anfield Stadium, this multi-faceted business is an exciting and rare opportunity.
"We are currently seeing increased demand for wet-led public houses, so we expect the sale to attract attention from a wide variety of buyers."